Translations:Celiac disease/2/en

Schematic of the Marsh classification of upper jejunal pathology in coeliac disease.

• Also known as “Celiac Sprue”
• Affects 0.6 to 1.0% of worldwide population
• Occurs in industrialized countries and developing countries among all ethnicities and races
• Occurs in children and adults
• 1.5 to 2 times more prevalent in females than in males
• Gluten is found in wheat, rye, and barley
• Associated with strong family history, Type 1 DM, autoimmune thyroid disorders along with other autoimmune disorders, Turner’s syndrome, and Down syndrome
• Rotavirus infection in children increases risk of developing disease
• Breastfeeding reported to reduce risk by 50%
• MHC class II proteins HLA-DQ2 (90%) and HLA-DQ8 are expressed in almost all of patients affected by Celiac disease