Template:Endocarditis Empiric Antibiotics
Revision as of 14:43, 7 July 2014 by Ostermayer (talk | contribs)
Native Valves
Options:
- Ampicillin/Sulbactam 12g/day IV in 4 doses + Gentamicin 3mg/kg/day IV in 2 or 3 doses
- Amoxicillin/Clavulanate 12g/day in 4 doses + Gentamicin 3mg/kg/day IV in 2 or 3 doses
- Oxacillin 2g IV six times daily or Nafcillin 2g IV six times daily + Gentamicin 1mg/kg IV three times daily AND Ampicillin 2g IV six times daily
- Daptomycin 6mg/kg IV once daily
Suspected MRSA:
- Vancomycin 30mg/kg/day IV in 2 doses PLUS
- Gentamicin 3mg/kg/day IV in 2 or 3 doses PLUS
- Ciprofloxacin 1000mg/day PO in 2 doses or 800 mg/day IV in 2 doses
Prosthetic Valves (Early)
- Early prosthetic valve endocarditis defined as < 12 months post surgery
- Vancomycin 30mg/kg/day IV in 2 doses PLUS
- Gentamicin 3mg/kg/day IV in 2 or 3 doses PLUS
- Rifampin 1200 mg/day PO in 2 doses
Prosthetic Valve (Late)
- Late prosthetic valve endocarditis defined as ≥ 12 months post surgery
- Same as native valve endocarditis empiric therapy