Template:Anthrax antibiotics: Difference between revisions
(Add Imipenem/Cilastatin and Rifampin AntibioticDose entries for systemic anthrax) |
(Add Imipenem/Cilastatin and Rifampin AntibioticDose entries for systemic anthrax) |
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*{{AntibioticDose|disease=Anthrax|drug=Doxycycline|dose=2.2mg/kg IV q12hrs|context=Pediatric; only if allergic to cipro|population=Pediatric}} '''PLUS''' | *{{AntibioticDose|disease=Anthrax|drug=Doxycycline|dose=2.2mg/kg IV q12hrs|context=Pediatric; only if allergic to cipro|population=Pediatric}} '''PLUS''' | ||
**{{AntibioticDose|disease=Anthrax|drug=Clindamycin|dose=7.5mg/kg q6hrs|context=Pediatric; combined with Ciprofloxacin or Doxycycline|population=Pediatric}} | **{{AntibioticDose|disease=Anthrax|drug=Clindamycin|dose=7.5mg/kg q6hrs|context=Pediatric; combined with Ciprofloxacin or Doxycycline|population=Pediatric}} | ||
*{{AntibioticDose|drug=Imipenem/Cilastatin|dose=1g IV q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Adult}} | |||
*{{AntibioticDose|drug=Imipenem/Cilastatin|dose=Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}} | |||
*{{AntibioticDose|drug=Rifampin|dose=600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure|context=Anthrax, systemic|disease=Anthrax|population=Adult}} | |||
*{{AntibioticDose|drug=Rifampin|dose=Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}} | |||
*{{AntibioticDose|drug=Imipenem/Cilastatin|dose=1g IV q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Adult}} | *{{AntibioticDose|drug=Imipenem/Cilastatin|dose=1g IV q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Adult}} | ||
*{{AntibioticDose|drug=Imipenem/Cilastatin|dose=Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}} | *{{AntibioticDose|drug=Imipenem/Cilastatin|dose=Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}} | ||
*{{AntibioticDose|drug=Rifampin|dose=600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure|context=Anthrax, systemic|disease=Anthrax|population=Adult}} | *{{AntibioticDose|drug=Rifampin|dose=600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure|context=Anthrax, systemic|disease=Anthrax|population=Adult}} | ||
*{{AntibioticDose|drug=Rifampin|dose=Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}} | *{{AntibioticDose|drug=Rifampin|dose=Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}} | ||
Latest revision as of 10:52, 20 March 2026
Postexposure Prophylaxis
Patient should be vaccinated at day #0, #14, #28
- Ciprofloxacin 500mg PO q12hrs x 60 days OR
- Doxycycline 100mg PO q12hrs x 60 days
Cutaneous Anthrax (not systemically ill)
- Ciprofloxacin 500mg PO q12hrs x 60 days
- Doxycycline 100mg PO q12hrs x 60 days
Inhalation or Cutaneous with systemic illness
- Ciprofloxacin 400mg IV q12hrs x 60 days OR
- Doxycycline 100mg IV q12hrs x 60 days PLUS
- Clindamycin 900mg IV q8hrs
Pediatric Postexposure Prophylaxis
- Ciprofloxacin 15mg/kg PO q12hrs x 60 days
- Doxycycline 2.2mg/kg PO q12hrs x 60 days
Pediatric Cutaneous Anthrax (not ill)
- Same as pediatric postexposure dosing and duration
Pediatric Inhalational or Cutaneous (systemically ill)
- Ciprofloxacin 15mg/kg IV q12hrs OR
- Doxycycline 2.2mg/kg IV q12hrs PLUS
- Clindamycin 7.5mg/kg q6hrs
- Imipenem/Cilastatin 1g IV q6h for at least 2wk
- Imipenem/Cilastatin Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk
- Rifampin 600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure
- Rifampin Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose
- Imipenem/Cilastatin 1g IV q6h for at least 2wk
- Imipenem/Cilastatin Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk
- Rifampin 600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure
- Rifampin Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose