Template:Endometritis Antibiotics: Difference between revisions
(Convert to AntibioticDose template with disease=Postpartum endometritis for SMW linking) |
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====<48hrs Post Partum==== | ====<48hrs Post Partum==== | ||
''Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora'' | ''Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora'' | ||
*(Prefered first line) | *(Prefered first line) {{AntibioticDose|disease=Postpartum endometritis|drug=Clindamycin|dose=900mg IV q8hrs|context=First line less than 48hrs postpartum|population=Adult}} PLUS {{AntibioticDose|disease=Postpartum endometritis|drug=Gentamicin|dose=5mg/kg IV q24hrs or 1.5mg/kg IV q8hrs|context=First line less than 48hrs postpartum with Clindamycin|population=Adult}}<ref>Mackeen AD, Packard RE, Ota E, Speer L. Antibiotic regimens for postpartum endometritis. Cochrane Database Syst Rev. 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3. PMID: 25922861; PMCID: PMC7050613</ref> OR | ||
*[[Doxycycline]] 100mg IV PO q12hrs daily PLUS | *[[Doxycycline]] 100mg IV PO q12hrs daily PLUS | ||
** | **{{AntibioticDose|disease=Postpartum endometritis|drug=Ampicillin/Sulbactam|dose=3g IV q6hrs|context=Alt less than 48hrs postpartum with Doxycycline|population=Adult}} | ||
** | **{{AntibioticDose|disease=Postpartum endometritis|drug=Cefoxitin|dose=2g IV q6hrs|context=Alt less than 48hrs postpartum with Doxycycline|population=Adult}} | ||
====>48hrs Post Partum==== | ====>48hrs Post Partum==== | ||
* | *{{AntibioticDose|disease=Postpartum endometritis|drug=Doxycycline|dose=100mg IV or PO q12hrs|context=Greater than 48hrs postpartum|population=Adult}} + {{AntibioticDose|disease=Postpartum endometritis|drug=Metronidazole|dose=500mg IV or PO q8hrs|context=Greater than 48hrs postpartum with Doxycycline|population=Adult}} | ||
**Use Metronidazole with caution in breastfeeding mothers its active is present in breast milk at concentrations similar to maternal plasma concentrations | **Use Metronidazole with caution in breastfeeding mothers its active is present in breast milk at concentrations similar to maternal plasma concentrations | ||
Revision as of 01:17, 20 March 2026
<48hrs Post Partum
Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora
- (Prefered first line) Clindamycin 900mg IV q8hrs PLUS Gentamicin 5mg/kg IV q24hrs or 1.5mg/kg IV q8hrs[1] OR
- Doxycycline 100mg IV PO q12hrs daily PLUS
- Ampicillin/Sulbactam 3g IV q6hrs
- Cefoxitin 2g IV q6hrs
>48hrs Post Partum
- Doxycycline 100mg IV or PO q12hrs + Metronidazole 500mg IV or PO q8hrs
- Use Metronidazole with caution in breastfeeding mothers its active is present in breast milk at concentrations similar to maternal plasma concentrations
- ↑ Mackeen AD, Packard RE, Ota E, Speer L. Antibiotic regimens for postpartum endometritis. Cochrane Database Syst Rev. 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3. PMID: 25922861; PMCID: PMC7050613