Pregnancy (main): Difference between revisions

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==Background==
==Background==
*[[Maternal Vitals and Labs in Pregnancy]]  
*[[Maternal Vitals and Labs in Pregnancy]]  
*[[Drug Ratings in Pregnancy]]
 
==Clinical Features==
*[[Fundal Exam in Pregnancy]]
*[[Fundal Exam in Pregnancy]]


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{{Postpartum emergencies DDX}}
{{Postpartum emergencies DDX}}
==Evaluation==
{{Repeat B-hCG levels}}
==Management==
*[[Drug Ratings in Pregnancy]]


==See Also==
==See Also==

Revision as of 21:14, 22 June 2020

Background

Clinical Features

Differential Diagnosis

Abdominal distention

Vaginal Bleeding in Pregnancy (<20wks)


Abdominal Pain in Pregnancy

The same abdominal pain differential as non-pregnant patients, plus:

<20 Weeks


>20 Weeks


Any time

3rd Trimester/Postpartum Emergencies

Evaluation

Repeat B-hCG Levels

Pregnancy Type B-hCG Change
Normal
  • Minimum expected rise depends on initial hCG value:[1][2]
    • Initial hCG <1,500 mIU/mL: minimum 49% rise in 48hrs
    • Initial hCG 1,500-3,000 mIU/mL: minimum 40% rise in 48hrs
    • Initial hCG >3,000 mIU/mL: minimum 33% rise in 48hrs
  • hCG typically doubles approximately every 48-72 hours in early pregnancy
  • Rate of rise slows after hCG reaches approximately 6,000-10,000 mIU/mL
Ectopic
  • Increases or decreases more slowly than expected ("plateau")
  • Approximately 21% of ectopic pregnancies have a normal hCG rise[3]
Miscarriage
  • Expected to decline >21-35% in 48 hrs[4]
  • A single hCG level cannot reliably distinguish intrauterine from ectopic pregnancy[5]
  • The discriminatory zone (typically 1,500-3,500 mIU/mL depending on institution) is the hCG level above which a gestational sac should be visible on transvaginal ultrasound[6]

Management

See Also

  1. Barnhart KT, Sammel MD, Rinaudo PF, et al. Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. Obstet Gynecol. 2004; 104(1):50-55. PMID 15229000.
  2. Barnhart KT, Guo W, Cary MS, et al. Differences in serum human chorionic gonadotropin rise in early pregnancy by race and value at presentation. Obstet Gynecol. 2016; 128(3):504-511. PMID 27500347.
  3. Silva C, Sammel MD, Zhou L, et al. Human chorionic gonadotropin profile for women with ectopic pregnancy. Obstet Gynecol. 2006; 107(3):605-610. PMID 16507930.
  4. Doubilet PM, Benson CB, Bourne T, Blaivas M. Diagnostic criteria for nonviable pregnancy early in the first trimester. N Engl J Med. 2013; 369(15):1443-1451. PMID 24106937.
  5. Murray H, Baakdah H, Bardell T, Tulandi T. Diagnosis and treatment of ectopic pregnancy. CMAJ. 2005; 173(8):905-912. PMID 16217116.
  6. Connolly A, Ryan DH, Stuber AR, Postma HJ. Reevaluation of discriminatory and threshold levels for serum beta-hCG in early pregnancy. Obstet Gynecol. 2013; 121(1):65-70. PMID 23262929.