Acanthosis nigricans: Difference between revisions
| Line 15: | Line 15: | ||
**Up to 50% of malignant acanthosis nigricans have oral involvement | **Up to 50% of malignant acanthosis nigricans have oral involvement | ||
**Rapid appearance of lesions | **Rapid appearance of lesions | ||
**Extensive involvement | **Extensive involvement | ||
**Older adult | **Older adult | ||
**Unexplained weight loss | **Unexplained weight loss | ||
**Lesions in atypical sites such as palms/soles, mucous membranes | **Lesions in atypical sites such as palms/soles, mucous membranes | ||
[[File:malignant_acanthosis_nigricans_ovarian.png|thumbnail]] | |||
==See Also== | ==See Also== | ||
Revision as of 17:30, 31 October 2019
Background
- Multiple forms, but malignant acanthosis nigricans is most important
- Clinically indistinguishable from benign form
Clinical Features
- Hyperpigmented, velvety
- Plaques
- Most commonly intertriginous areas, posterior neck
- May have concurrent acrochordons, skin tags
Malignant Acanthosis Nigricans[1]
- Associated with other dermal manifestations of internal cancers
- Most commonly associated with colonic adenocarcinoma, gastric cancer, ovarian cancer
- Red flags:
- Up to 50% of malignant acanthosis nigricans have oral involvement
- Rapid appearance of lesions
- Extensive involvement
- Older adult
- Unexplained weight loss
- Lesions in atypical sites such as palms/soles, mucous membranes
See Also
References
- ↑ Miller JH et al. Acanthosis Nigricans Clinical Presentation. eMedicine. Dec 3, 2015. http://emedicine.medscape.com/article/1102488-clinical#showall.