Paget-Schroetter syndrome: Difference between revisions

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==Background==
==Background==
*Thrombosis of the axillary and/or subclavian vein associated with repetitive movements of the upper extremity, such as those with sporting events (e.g. swimming, wrestling, etc)<ref name="Alla">Alla, V. M., Natarajan, N., Kaushik, M., Warrier, R., & Nair, C. K. (2010). Paget-Schroetter Syndrome: Review of Pathogenesis and Treatment of Effort Thrombosis. Western Journal of Emergency Medicine, 11(4), 358–362.</ref>
*Thrombosis of the axillary and/or subclavian vein associated with repetitive movements of the upper extremity, such as those with sporting events (e.g. swimming, wrestling, etc)<ref name="Alla">Alla, V. M., Natarajan, N., Kaushik, M., Warrier, R., & Nair, C. K. (2010). Paget-Schroetter Syndrome: Review of Pathogenesis and Treatment of Effort Thrombosis. Western Journal of Emergency Medicine, 11(4), 358–362.</ref>
**Usually affects dominant arm
*Usually affects dominant arm
*May be acute, subacute or chronic
*May be acute, subacute or chronic


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==Evaluation==
==Evaluation==
*CBC, CMP, coags
*Doppler ultrasound is preferred test
*consider D-dimer
*CTV or MRV have higher sensitivity/specificity if continued clinical concern
*Chest X-ray
*May also consider:
**To rule out anatomic abnormalities or lung masses that might cause thoracic outlet obstruction
**CXR to evaluate for causes of thoracic outlet obstruction
*Ultrasound with color Doppler
**Laboratory testing
**Preferred initial test (sensitivity 78-100%, specificity 82-100%)
*MRI venography
**noninvasive, but expensive and limited availability
*Gold standard = contrast venography
**Use when ultrasound findings are equivocal but still have high clinical suspicion


==Management==
==Management==
#Anticoagulation
[[File:PSS.jpg|thumb|Paget-Schroetter syndrome treatment]]
#*[[LMWH]], Fondaparinux, [[Unfractionated Heparin]]
*Catheter-directed thrombolysis is first-line treatment for acute disease (<2-6 weeks duration)<ref name="Alla" />
#**Choice depends on further plans for intervention and disposition
*Consider surgical thoracic outlet decompression (TOD) for chronic disease or failure of catheter-directed thrombolysis
#**Bridge to [[Coumadin]]
*'''Anticoagulation alone is not recommended due to high rates of morbidity'''
#Thrombolysis
#*Catheter directed infusion of alteplase or urokinase
#*For moderate to severe cases
#Surgical decompression
#*For moderate to severe cases


==Disposition==
==Disposition==
*Depends on the severity of symptoms and the acuity of presentation
*Admit
**Mild/intermittent/chronic (>2weeks) symptoms
***Outpatient management with LMWH bridging to Coumadin
**Severe/acute presentation
***Admit, consult vascular surgery for thrombectomy or thrombolysis


==See Also==
==See Also==

Revision as of 00:18, 10 July 2017

Background

  • Thrombosis of the axillary and/or subclavian vein associated with repetitive movements of the upper extremity, such as those with sporting events (e.g. swimming, wrestling, etc)[1]
  • Usually affects dominant arm
  • May be acute, subacute or chronic

Clinical Features

  • Arm swelling, pain
  • Redness of the upper extremity
  • Dilated, visible veins around the shoulder (Urschel’s sign)
  • Most patients report a precipitating event, generally sports-related arm exertion[1]

Differential Diagnosis

Upper extremity swelling

Evaluation

  • Doppler ultrasound is preferred test
  • CTV or MRV have higher sensitivity/specificity if continued clinical concern
  • May also consider:
    • CXR to evaluate for causes of thoracic outlet obstruction
    • Laboratory testing

Management

Paget-Schroetter syndrome treatment
  • Catheter-directed thrombolysis is first-line treatment for acute disease (<2-6 weeks duration)[1]
  • Consider surgical thoracic outlet decompression (TOD) for chronic disease or failure of catheter-directed thrombolysis
  • Anticoagulation alone is not recommended due to high rates of morbidity

Disposition

  • Admit

See Also

References

  1. 1.0 1.1 1.2 Alla, V. M., Natarajan, N., Kaushik, M., Warrier, R., & Nair, C. K. (2010). Paget-Schroetter Syndrome: Review of Pathogenesis and Treatment of Effort Thrombosis. Western Journal of Emergency Medicine, 11(4), 358–362.