Grey baby syndrome: Difference between revisions
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==Background== | ==Background== | ||
*A side effect of chloramphenicol affecting newborns of mothers who have been exposed to the drug | *A side effect of [[chloramphenicol]] affecting newborns of mothers who have been exposed to the drug | ||
*Thought to be related to insufficient ability of the newborn's liver to metabolize the drug, as well as insufficient renal excretion | *Thought to be related to insufficient ability of the newborn's liver to metabolize the drug, as well as insufficient renal excretion | ||
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*Symptoms usually occur within 1 week of exposure and include: | *Symptoms usually occur within 1 week of exposure and include: | ||
**Ashen gray color of the skin | **Ashen gray color of the skin | ||
**Failure to thrive | **[[failure to thrive (peds)|Failure to thrive]] | ||
*Poor appetite | **Poor appetite | ||
**Vomiting | **[[nausea and vomiting (peds)|Vomiting]] | ||
**Hypotension | **[[Hypotension]] | ||
**Hypothermia | **[[Hypothermia]] | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Sick neonate DDX}} | |||
==Evaluation== | ==Evaluation== | ||
*Assess for alternate diagnoses | |||
==Management== | ==Management== | ||
*Stop [[chloramphenicol]] exposure | |||
*[[Exchange transfusion]] | |||
*Sometimes [[phenobarbital]] used for UGT induction | |||
==Disposition== | ==Disposition== | ||
*Admit | |||
==See Also== | ==See Also== | ||
Latest revision as of 22:02, 5 October 2019
Background
- A side effect of chloramphenicol affecting newborns of mothers who have been exposed to the drug
- Thought to be related to insufficient ability of the newborn's liver to metabolize the drug, as well as insufficient renal excretion
Clinical Features
- Symptoms usually occur within 1 week of exposure and include:
- Ashen gray color of the skin
- Failure to thrive
- Poor appetite
- Vomiting
- Hypotension
- Hypothermia
Differential Diagnosis
Sick Neonate
THE MISFITS [1]
- Trauma
- Heart
- Congenital heart disease
- Hypovolemia
- Endocrine
- Metabolic
- Sodium
- Calcium
- Glucose
- Inborn errors of metabolism
- Seizure
- Formula / feeding problems
- Intestinal Disasters
- Toxin
- Sepsis
Evaluation
- Assess for alternate diagnoses
Management
- Stop chloramphenicol exposure
- Exchange transfusion
- Sometimes phenobarbital used for UGT induction
Disposition
- Admit
See Also
External Links
References
- ↑ Brousseau T, Sharieff GQ. Newborn emergencies: the first 30 days of life. Pediatr Clin North Am. 2006 Feb;53(1):69-84, vi.