Template:Anthrax antibiotics: Difference between revisions

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(Add Imipenem/Cilastatin and Rifampin AntibioticDose entries for systemic anthrax)
 
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====Postexposure Prophylaxis====
====Postexposure Prophylaxis====
''Patient should be vaccinated at day #0, #14, #28''
''Patient should be vaccinated at day #0, #14, #28''
*[[Special:MyLanguage/Ciprofloxacin|Ciprofloxacin]] 500mg PO q12hrs daily x 60 days '''OR'''
*{{AntibioticDose|disease=Anthrax|drug=Ciprofloxacin|dose=500mg PO q12hrs x 60 days|context=Postexposure prophylaxis}} '''OR'''
*[[Special:MyLanguage/Doxycycline|Doxycycline]] 100mg PO q12hrs x 60 days
*{{AntibioticDose|disease=Anthrax|drug=Doxycycline|dose=100mg PO q12hrs x 60 days|context=Postexposure prophylaxis}}
 
 
====Cutaneous Anthrax (not systemically ill)====
====Cutaneous Anthrax (not systemically ill)====
 
*{{AntibioticDose|disease=Anthrax|drug=Ciprofloxacin|dose=500mg PO q12hrs x 60 days|context=Cutaneous anthrax, not systemically ill}}
*Ciprofloxacin 500mg PO q12hrs x 60 days
*{{AntibioticDose|disease=Anthrax|drug=Doxycycline|dose=100mg PO q12hrs x 60 days|context=Cutaneous anthrax, not systemically ill}}
*Doxycycline 100mg PO q12hrs x 60 days
 
 
====Inhalation or Cutaneous with systemic illness====
====Inhalation or Cutaneous with systemic illness====
 
*{{AntibioticDose|disease=Anthrax|drug=Ciprofloxacin|dose=400mg IV q12hrs x 60 days|context=Inhalation or cutaneous with systemic illness; 1st line}} '''OR'''
*[[Special:MyLanguage/Ciprofloxacin|Ciprofloxacin]] 400mg IV q12hrs x 60 days (1st line) '''OR'''
*{{AntibioticDose|disease=Anthrax|drug=Doxycycline|dose=100mg IV q12hrs x 60 days|context=Inhalation/cutaneous with systemic illness; only if allergic to ciprofloxacin}} '''PLUS'''
*[[Special:MyLanguage/Doxycycline|Doxycycline]] 100mg IV q12hrs x 60days (only if allergic to ciprofloxacin) '''PLUS'''
**{{AntibioticDose|disease=Anthrax|drug=Clindamycin|dose=900mg IV q8hrs|context=Inhalation/cutaneous with systemic illness; combined with Ciprofloxacin or Doxycycline}}
**[[Special:MyLanguage/Clindamycin|Clindamycin]] 900mg IV q8hrs
====Pediatric Postexposure Prophylaxis====
 
*{{AntibioticDose|disease=Anthrax|drug=Ciprofloxacin|dose=15mg/kg PO q12hrs x 60 days|context=Pediatric postexposure prophylaxis|population=Pediatric}}
 
*{{AntibioticDose|disease=Anthrax|drug=Doxycycline|dose=2.2mg/kg PO q12hrs x 60 days|context=Pediatric postexposure prophylaxis|population=Pediatric}}
====Pediatric Postexpsoure Prophylaxis====
 
*[[Special:MyLanguage/Ciprofloxacin|Ciprofloxacin]] 15mg/kg PO q12hrs x 60 days
*[[Special:MyLanguage/Doxycycline|Doxycycline]] 2.2mg/kg PO q12hrs x 60 days
 
 
====Pediatric Cutaneous Anthrax (not ill)====
====Pediatric Cutaneous Anthrax (not ill)====
 
*Same as pediatric postexposure dosing and duration
*Same as post exposure dosing and duration
====Pediatric Inhalational or Cutaneous (systemically ill)====
 
*{{AntibioticDose|disease=Anthrax|drug=Ciprofloxacin|dose=15mg/kg IV q12hrs|context=Pediatric inhalational/cutaneous, systemically ill; 1st line|population=Pediatric}} '''OR'''
 
*{{AntibioticDose|disease=Anthrax|drug=Doxycycline|dose=2.2mg/kg IV q12hrs|context=Pediatric; only if allergic to cipro|population=Pediatric}} '''PLUS'''
====Pediatric Inhalational or Cutaneous (systemically ill====
**{{AntibioticDose|disease=Anthrax|drug=Clindamycin|dose=7.5mg/kg q6hrs|context=Pediatric; combined with Ciprofloxacin or Doxycycline|population=Pediatric}}
 
*{{AntibioticDose|drug=Imipenem/Cilastatin|dose=1g IV q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Adult}}
*[[Special:MyLanguage/Ciprofloxacin|Ciprofloxacin]] 15mg/kg IV q12hrs (1st line) '''OR'''
*{{AntibioticDose|drug=Imipenem/Cilastatin|dose=Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}}
*[[Special:MyLanguage/Doxycycline|Doxycycline]] 2.2mg/kg IV q12hrs (only if allergic to cipro) '''PLUS'''
*{{AntibioticDose|drug=Rifampin|dose=600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure|context=Anthrax, systemic|disease=Anthrax|population=Adult}}
**[[Special:MyLanguage/Clindamycin|Clindamycin]] 7.5mg/kg q6hrs daily
*{{AntibioticDose|drug=Rifampin|dose=Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}}
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*{{AntibioticDose|drug=Imipenem/Cilastatin|dose=1g IV q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Adult}}
*{{AntibioticDose|drug=Imipenem/Cilastatin|dose=Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}}
*{{AntibioticDose|drug=Rifampin|dose=600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure|context=Anthrax, systemic|disease=Anthrax|population=Adult}}
*{{AntibioticDose|drug=Rifampin|dose=Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose|context=Anthrax, systemic|disease=Anthrax|population=Pediatric}}

Latest revision as of 10:52, 20 March 2026

Postexposure Prophylaxis

Patient should be vaccinated at day #0, #14, #28

Cutaneous Anthrax (not systemically ill)

Inhalation or Cutaneous with systemic illness

Pediatric Postexposure Prophylaxis

Pediatric Cutaneous Anthrax (not ill)

  • Same as pediatric postexposure dosing and duration

Pediatric Inhalational or Cutaneous (systemically ill)

  • Ciprofloxacin 15mg/kg IV q12hrs OR
  • Doxycycline 2.2mg/kg IV q12hrs PLUS
  • Imipenem/Cilastatin 1g IV q6h for at least 2wk
  • Imipenem/Cilastatin Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk
  • Rifampin 600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure
  • Rifampin Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose
  • Imipenem/Cilastatin 1g IV q6h for at least 2wk
  • Imipenem/Cilastatin Neonates >32 wk gestation; 40-75 mg/kg/day IV divided q8-12h for at least 2wk; 1 month and older; 100 mg/kg/day IV divided q6h for at least 2wk
  • Rifampin 600 mg IV q12h for at least 2 wk as part of a multi-drug regimen; Switch to PO abx x60 days total if inhalational exposure
  • Rifampin Neonates >32 wk gestation; 10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen; 1+ mo; 20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen; Max: 300 mg/dose
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