Enalaprilat: Difference between revisions
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**CrCl <30 | **CrCl <30 | ||
**Severe volume or salt depletion, recent HD, or concomitant diuretic use | **Severe volume or salt depletion, recent HD, or concomitant diuretic use | ||
**CHF | **[[CHF]] | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
''Safety/efficacy not established'' | ''Safety/efficacy not established'' | ||
| Line 29: | Line 29: | ||
*Angioedema | *Angioedema | ||
===Common=== | ===Common=== | ||
*Hyperkalemia | *[[Hyperkalemia]] | ||
*Nausea | *Nausea | ||
*Headache | *Headache | ||
| Line 40: | Line 40: | ||
*Inhibits angiotensin converting enzyme, blocking conversion of angiotensin I to angiotensin II. | *Inhibits angiotensin converting enzyme, blocking conversion of angiotensin I to angiotensin II. | ||
==Comments== | ==Comments== | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Enalaprilat]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
*[[Hypertension]] | |||
*[[ACE inhibitor]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Cardiology]] | |||
Latest revision as of 21:56, 20 March 2026
Administration
- Type: ACE inhibitor
- Dosage Forms:
- Routes of Administration: IV
- Common Trade Names: Vasotec
Adult Dosing
- 1.25-5mg IV q6h
- 0.625mg IV initially, with repeated dose of 0.625mg if inadequate response for the following patients:
- CrCl <30
- Severe volume or salt depletion, recent HD, or concomitant diuretic use
- CHF
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk minimal
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
- Angioedema history (ACEi-induced, hereditary, or idiopathic)
Adverse Reactions
Serious
- Myocardial infarction
- Liver failure
- Angioedema
Common
- Hyperkalemia
- Nausea
- Headache
Pharmacology
- Half-life: ~11h
- Metabolism:
- Excretion: Renal. Dialyzable
Mechanism of Action
- Inhibits angiotensin converting enzyme, blocking conversion of angiotensin I to angiotensin II.
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Congestive heart failure | 0.004 mg/kg IV bolus or 1 mg IV drip over 2 hours | ACE inhibitor for afterload reduction | IV | Adult |
| Hypertensive emergency | 0.625-1.25 mg IV q6 hr | ACE inhibitor | IV | Adult |