Quinine: Difference between revisions

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(Replace manual dosing with dynamic SMW tables)
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==Adult Dosing==
==Adult Dosing==
===[[Malaria]]===
===Indications by Disease===
*648mg PO Q8h x 7 days
{{#ask: [[Has DrugName::Quinine]] [[Has Population::Adult]]
*See [http://www.cdc.gov/malaria/resources/pdf/treatmenttable.pdf CDC Recommendations] for full treatment recommendations
|?Treats disease=Disease
 
|?Has Dose=Dose
===[[Babesiosis]]===
|?Has Context=Context
*648mg PO q6-8h x7-10 days
|format=table
*Use with [[Clindamycin]]
|limit=50
|mainlabel=-
|headers=show
|sort=Treats disease
}}


==Pediatric Dosing==
==Pediatric Dosing==
===[[Malaria]]===
===Indications by Disease===
*30mg/kg/day PO q8h x 3-7 days
{{#ask: [[Has DrugName::Quinine]] [[Has Population::Pediatric]]
*Max: 648mg/dose
|?Treats disease=Disease
*See [http://www.cdc.gov/malaria/resources/pdf/treatmenttable.pdf CDC Recommendations] for full treatment recommendations
|?Has Dose=Dose
 
|?Has Context=Context
===[[Babesiosis]]===
|format=table
*8mg/kg PO q8h x 7-10 days
|limit=50
*Max: 648mg/dose
|mainlabel=-
*Use with [[Clindamycin]]
|headers=show
|sort=Treats disease
}}


==Special Populations==
==Special Populations==

Revision as of 01:54, 20 March 2026

General

  • Type: Antimalarial
  • Dosage Forms: PO 324 (IM and IV formulations available outside US)
  • Common Trade Names: Qualaquin

Adult Dosing

Indications by Disease

DiseaseDoseContext
Babesiosis650mg TIDSevere parasitemia with Clindamycin use IV for severe
Malaria648mg PO q8h x 7 daysUncomplicated malaria, use with doxycycline or clindamycin

Pediatric Dosing

Indications by Disease

DiseaseDoseContext
Babesiosis8mg/kg PO q8h x 7-10 days (Max: 648mg/dose)Severe parasitemia with Clindamycin
Malaria30mg/kg/day PO q8h x 3-7 days (Max: 648mg/dose)Uncomplicated malaria, use with clindamycin

Special Populations

  • Pregnancy Rating: C
  • Lactation: Probably safe
  • Renal Dosing
    • Adult
      • Severe chronic renal failure: 648mg PO x 1 then 324mg PO q12h
      • If on HD give after dialysis
    • Pediatric
      • Not defined
  • Hepatic Dosing
    • Adult and Pediatric
      • No adjustment for Child-Pugh Class A or B
      • Avoid in Child-Pugh Class C

Contraindications

Black Box Warnings

  • Hematologic Toxicity with use for nocturnal leg cramps

General

Caution

Adverse Reactions

Serious

Common

  • Cinchonism
  • Headache
  • Vasodilation
  • Diaphoresis
  • Nausea/Vomiting
  • Tinnitus
  • Impaired hearing
  • Vertigo
  • Visual impairment
  • Fever
  • Flushing
  • asthenia
  • Rash
  • Pruritus
  • Urticaria
  • Diarrhea
  • Abdominal pain
  • Photosensitivity

Pharmacology

  • Half-life: 9-12 hours
  • Metabolism: Liver 80%, CYP450
  • Excretion: Urine
  • Mechanism of Action: Unknown

Administration

  • Give with food

Toxicity

  • Mild
    • Nausea
    • Vomiting
    • Tinnitus
    • Vertigo
    • Deafness
  • Severe
    • Ataxia
    • Convulsions
    • Coma
    • QRS/QT prolongation
    • Arrhythmia
  • Retinal Toxicity
    • Blurry vision
    • Impaired visual fields
    • Blindness

See Also

References

  • Epocrates


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