Tobramycin - Revision history

Danbot: Add AntibioticDose SMW query table for dynamic indications by disease

2026-03-20T20:38:35Z

Add AntibioticDose SMW query table for dynamic indications by disease

@@ Line 16: / Line 16: @@
 ===[[Endocarditis]], Gram positive synergy===
 *3 mg/kg IV q24h for at least 2 weeks as part of multi-drug regimen
 ==Pediatric Dosing==
 ===[[Infection]], bacterial===
 *<8 days old

Ostermayer at 15:09, 18 July 2025

2025-07-18T15:09:34Z

← Older revision		Revision as of 15:09, 18 July 2025
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	==General==		==General==
	*Type: [[Aminoglycoside]]		*Type: [[Is DrugClass::Aminoglycoside]]
	*Dosage Forms: IV		*Dosage Forms: IV
	*Common Trade Names: Tobrex		*Common Trade Names: Tobrex

ClaireLewis: /* Refereces */

2019-09-23T23:04:10Z

Refereces

← Older revision		Revision as of 23:04, 23 September 2019
Line 217:		Line 217:
	==See Also==		==See Also==

	==~~Refereces~~==		==References==
	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Jonwarren: Drug dosing and information; adverse reactions; pharmacology

2017-10-04T17:44:31Z

Drug dosing and information; adverse reactions; pharmacology

← Older revision		Revision as of 17:44, 4 October 2017
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	==General==		==General==
	*Type: [[~~aminoglycoside~~]]		*Type: [[Aminoglycoside]]
	*Dosage Forms: IV~~, oral inhalation, opthalmic drops~~		*Dosage Forms: IV
	*Common Trade Names: Tobrex		*Common Trade Names: Tobrex
	*Nephro- and oto- toxic; can precipitate [[myasthenia gravis]] crisis

	==Adult Dosing==		==Adult Dosing==
	~~CrCl > 80:~~ 1 - 1.7 mg/kg ~~iv q 8 h.~~		===[[Infection]], bacterial===
	~~CrCl 80~~-50: ~~q 8~~ - ~~12 h~~.		*1-1.7 mg/kg IM/IV q8h
			*For extended interval dosing:
			**5-7 mg/kg IV q24h
			===[[Pneumonia]], Hospital-acquired===
			*5-7 mg/kg IV q24h x7 days
			===Respiratory infections, [[Cystic fibrosis]] pts===
			*10-12 mg/kg IV q24h
			*Alt: 2.5-3.5 mg/kg IV q8h
			===[[Endocarditis]], Gram positive synergy===
			*3 mg/kg IV q24h for at least 2 weeks as part of multi-drug regimen

	==Pediatric Dosing==		==Pediatric Dosing==
			===[[Infection]], bacterial===
			*<8 days old
			**2 mg/kg IV/IM q12h
			*>8 days old
			**2-2.5 mg/kg IV/IM q8h
			===Respiratory infections, [[Cystic fibrosis]] pts===
			*>1 mo
			**10-12 mg/kg IV q24h
			===Febrile [[neutropenia]], post-stem cell transplant===
			*<5 yo
			**9 mg/kg IV q 24h
			*5-11 yo
			**8 mg/kg IV q24h
			*12+ yo
			**7 mg/kg IV q24h
			===[[Endocarditis]], Gram positive synergy===
			*3-6 mg/kg IV divided q8h as part of multi-drug regimen

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*Lactation:		*Lactation: May use, no known risk based on drug properties
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult
	***CrCl 50-10: 1 - ~~1.7 mg/kg iv q 12- 48 hrs~~		***CrCl 50-70: Give q8-24h
	***CrCl < 10: ~~> 1~~ - ~~1.7 mg/kg iv q 48, dose on peak/trough levels~~		***CrCl 10-50: Give q24-48h
	***~~Hemodialysis~~: ~~1 mg/kg~~ after dialysis		***CrCl <10: Give q48-72h
			***HD: Give 50% usual dose after dialysis
			***PD: Give supplement
	**Pediatric		**Pediatric
			***CrCl 30-50: Give q12-18h
			***CrCl 10-29: Give q18-24h
			***CrCl <10: Give q48-72h
			***HD/PD: 2 mg/kg x1 then adjust dose based on serum
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult
			***Not defined
	**Pediatric		**Pediatric
			***Not defined

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*Caution:
			**Hypersensitivity to sulfites
			**Renal Impairment
			**Dehydration
			**Concurrent nephrotoxic/ototoxic agent
			**Impaired auditory/vestibular fxn
			**Neuromuscular dz
			**Prolonged use

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Ototoxicity, auditory or vestibular
			*Nephrotoxicity, Neurotoxicity
			*Neuromuscular blockaed
			*Superinfection
			*C. Diff associated [[diarrhea]]
			*[[Anaphylaxis]]
			*Hypersensitivity rxn
			*Exfoliative Dermatitis
			*Toxic epidermal necrolysis, [[Stevens-Johnson Syndrome]]
			*Erythema multiforme

	===Common===		===Common===
			*BUN, Cr elevation
			*[[Dizziness]], [[vertigo]]
			*[[Tinnitus]], hearing loss
			*Injection site rxn

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 2h
	*Metabolism:		*Metabolism: Minimal to none
	*Excretion: ~~renal~~		*Excretion: Renal (100% unchanged)
	*Mechanism of Action:		*Mechanism of Action: Binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis

	==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==		==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Mholtz at 23:16, 30 August 2017

2017-08-30T23:16:24Z

← Older revision		Revision as of 23:16, 30 August 2017
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	*Type: [[aminoglycoside]]		*Type: [[aminoglycoside]]
	*Dosage Forms: IV, oral inhalation, opthalmic drops		*Dosage Forms: IV, oral inhalation, opthalmic drops
	*Common Trade Names:		*Common Trade Names: Tobrex
	*Nephro- and oto- toxic; can precipitate [[myasthenia gravis]] crisis		*Nephro- and oto- toxic; can precipitate [[myasthenia gravis]] crisis

Line 160:		Line 160:
	===Key===		===Key===
	{{Template:Antibacterial Spectra Key}}		{{Template:Antibacterial Spectra Key}}

	==See Also==		==See Also==

	==~~Source~~==		==Refereces==

	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Mholtz: Text replacement - "* " to "*"

2017-07-13T02:16:49Z

Text replacement - "* " to "*"

← Older revision		Revision as of 02:16, 13 July 2017
Line 3:		Line 3:
	*Dosage Forms: IV, oral inhalation, opthalmic drops		*Dosage Forms: IV, oral inhalation, opthalmic drops
	*Common Trade Names:		*Common Trade Names:
	* Nephro- and oto- toxic; can precipitate [[myasthenia gravis]] crisis		*Nephro- and oto- toxic; can precipitate [[myasthenia gravis]] crisis

	==Adult Dosing==		==Adult Dosing==

Unenthusiastic: /* Pharmacology */

2017-03-18T07:53:10Z

Pharmacology

← Older revision		Revision as of 07:53, 18 March 2017
Line 36:		Line 36:
	*Half-life:		*Half-life:
	*Metabolism:		*Metabolism:
	*Excretion:		*Excretion: renal
	*Mechanism of Action:		*Mechanism of Action:

Unenthusiastic: /* General */

2017-03-18T07:51:20Z

General

← Older revision		Revision as of 07:51, 18 March 2017
Line 1:		Line 1:
	==General==		==General==
	*Type:		*Type: [[aminoglycoside]]
	*Dosage Forms: IV		*Dosage Forms: IV, oral inhalation, opthalmic drops
	*Common Trade Names:		*Common Trade Names:
	* Nephro- and oto- toxic; can precipitate [[myasthenia gravis]] crisis		* Nephro- and oto- toxic; can precipitate [[myasthenia gravis]] crisis

Unenthusiastic: /* Adult Dosing */

2017-03-18T07:49:50Z

Adult Dosing

← Older revision		Revision as of 07:49, 18 March 2017
Line 8:		Line 8:
	CrCl > 80: 1 - 1.7 mg/kg iv q 8 h.		CrCl > 80: 1 - 1.7 mg/kg iv q 8 h.
	CrCl 80-50: q 8 - 12 h.		CrCl 80-50: q 8 - 12 h.


	.

	==Pediatric Dosing==		==Pediatric Dosing==

Unenthusiastic: /* General */

2017-03-18T07:49:38Z

General

← Older revision		Revision as of 07:49, 18 March 2017
Line 3:		Line 3:
	*Dosage Forms: IV		*Dosage Forms: IV
	*Common Trade Names:		*Common Trade Names:
	* Nephro- and oto- toxic.		* Nephro- and oto- toxic; can precipitate [[myasthenia gravis]] crisis

	==Adult Dosing==		==Adult Dosing==