Template:Myasthenic vs cholinergic crisis - Revision history

Rossdonaldson1: /* Myasthenic versus cholinergic crisis */

2018-09-13T19:26:39Z

Myasthenic versus cholinergic crisis

← Older revision		Revision as of 19:26, 13 September 2018
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	===[[Myasthenia gravis\|Myasthenic]] versus [[cholinergic crisis]]===		===[[Myasthenia gravis\|Myasthenic]] versus [[cholinergic crisis]]===
	''Flaccid paralysis resulting from [[cholinergic crisis]] can be distinguished from [[myasthenia gravis]] by the use of the drug [[edrophonium]], which worsens the paralysis caused by cholinergic crisis, but strengthens the muscle in the case of myasthenia gravis. (Edrophonium is an cholinesterase inhibitor hence increases the concentration of acetylcholine present).''		''Flaccid paralysis resulting from cholinergic crisis can be distinguished from [[myasthenia gravis]] by the use of the drug [[edrophonium]], which worsens the paralysis caused by cholinergic crisis, but strengthens the muscle in the case of myasthenia gravis. (Edrophonium is an cholinesterase inhibitor hence increases the concentration of acetylcholine present).''
	*Myasthenic Crisis		*Myasthenic Crisis
	**Respiratory failure is feared complication		**Respiratory failure is feared complication

Rossdonaldson1: /* Myasthenic versus cholinergic crisis */

2018-09-13T19:21:45Z

Myasthenic versus cholinergic crisis

← Older revision		Revision as of 19:21, 13 September 2018
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	===[[Myasthenia gravis\|Myasthenic]] versus [[cholinergic crisis]]===		===[[Myasthenia gravis\|Myasthenic]] versus [[cholinergic crisis]]===
			''Flaccid paralysis resulting from [[cholinergic crisis]] can be distinguished from [[myasthenia gravis]] by the use of the drug [[edrophonium]], which worsens the paralysis caused by cholinergic crisis, but strengthens the muscle in the case of myasthenia gravis. (Edrophonium is an cholinesterase inhibitor hence increases the concentration of acetylcholine present).''
	*Myasthenic Crisis		*Myasthenic Crisis
	**Respiratory failure is feared complication		**Respiratory failure is feared complication

Rossdonaldson1: /* Myasthenic versus cholinergic crisis */

2018-09-13T18:57:25Z

Myasthenic versus cholinergic crisis

← Older revision		Revision as of 18:57, 13 September 2018
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	===Myasthenic versus [[cholinergic crisis]]===		===[[Myasthenia gravis\|Myasthenic]] versus [[cholinergic crisis]]===
	*Myasthenic Crisis		*Myasthenic Crisis
	**Respiratory failure is feared complication		**Respiratory failure is feared complication

Rossdonaldson1 at 18:56, 13 September 2018

2018-09-13T18:56:34Z

← Older revision		Revision as of 18:56, 13 September 2018
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	===Myasthenic versus ~~Cholinergic Crisis~~===		===Myasthenic versus [[cholinergic crisis]]===
	*Myasthenic Crisis		*Myasthenic Crisis
	**Respiratory failure is feared complication		**Respiratory failure is feared complication

Rossdonaldson1: Created page with "===Myasthenic versus Cholinergic Crisis=== *Myasthenic Crisis Respiratory failure is feared complication Much more common **Due to medication non-adherence, infection, sur..."

2018-09-13T18:56:02Z

Created page with "===Myasthenic versus Cholinergic Crisis=== *Myasthenic Crisis **Respiratory failure is feared complication **Much more common **Due to medication non-adherence, infection, sur..."

New page

===Myasthenic versus Cholinergic Crisis===
*Myasthenic Crisis
**Respiratory failure is feared complication
**Much more common
**Due to medication non-adherence, infection, surgery, tapering of immunosuppressants, meds
*Cholinergic Crisis
**Excessive anticholinesterase medication may cause weakness and cholinergic symptoms
**Rarely if ever seen with dose limitation of pyridostigmine to less than 120mg q3hr
**If on usual dose of meds assume exacerbation due to MG even with cholinergic side effects
*[[Edrophonium]] (Tensilon) test to distinguish the two is controversial
**Give 1-2mg IV slow push. If any fasciculations, respiratory depression, or cholinergic symptoms within a few minutes, problem is likely cholinergic crisis (no more edrophonium). If no evidence of cholinergic excess, give total of 10mg and observe improvement in case of myasthenic crisis.
**Side effects of Edrophonium: Arrhythmias, Hypotension, Bronchospasm
**Thus, need to be on a monitor, with atropine on hand
**Treatment: Atropine

Template:Myasthenic vs cholinergic crisis - Revision history

Rossdonaldson1: /* Myasthenic versus cholinergic crisis */

Rossdonaldson1: /* Myasthenic versus cholinergic crisis */

Rossdonaldson1: /* Myasthenic versus cholinergic crisis */

Rossdonaldson1 at 18:56, 13 September 2018

Rossdonaldson1: Created page with "===Myasthenic versus Cholinergic Crisis=== *Myasthenic Crisis **Respiratory failure is feared complication **Much more common **Due to medication non-adherence, infection, sur..."

Rossdonaldson1: Created page with "===Myasthenic versus Cholinergic Crisis=== *Myasthenic Crisis Respiratory failure is feared complication Much more common **Due to medication non-adherence, infection, sur..."