Stevens-Johnson syndrome and toxic epidermal necrolysis - Revision history

Rossdonaldson1: /* Clinical Features */

2026-02-04T17:18:55Z

Clinical Features

← Older revision		Revision as of 17:18, 4 February 2026
Line 22:		Line 22:
	[[File:Stevens-johnson-syndrome.jpg\|thumbnail\|Stevens–Johnson syndrome]]		[[File:Stevens-johnson-syndrome.jpg\|thumbnail\|Stevens–Johnson syndrome]]
	[[File:SJS.jpg\|thumbnail\|Mucosal lesions with Stevens-Johnson]]		[[File:SJS.jpg\|thumbnail\|Mucosal lesions with Stevens-Johnson]]
			[[File:Stevens-Johnson Syndrome Conjunctivitis.jpg\|thumb\|Severe conjunctivitis from Stevens-Johnson]]
	*Often have prodrome ([[fever]], [[URI]] symptoms, [[headache]], malaise)		*Often have prodrome ([[fever]], [[URI]] symptoms, [[headache]], malaise)
	*Macular [[rash]]		*Macular [[rash]]

2024-12-11T18:15:31Z

Background

← Older revision		Revision as of 18:15, 11 December 2024
Line 1:		Line 1:
	==Background==		==Background==
			{{Skin anatomy background images}}
	* Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are a spectrum of disease which ultimately results in blistering and peeling of the skin		* Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are a spectrum of disease which ultimately results in blistering and peeling of the skin
	* Mucous membranes can also be involved		* Mucous membranes can also be involved

2023-07-03T12:56:07Z

Background

← Older revision		Revision as of 12:56, 3 July 2023
Line 1:		Line 1:
	==Background==		==Background==
	* Stevens-~~Johnoen~~ Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are a spectrum of disease which ultimately results in blistering and peeling of the skin		* Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are a spectrum of disease which ultimately results in blistering and peeling of the skin
	* Mucous membranes can also be involved		* Mucous membranes can also be involved
	*SJS and TEN exist on a spectrum of disease		*SJS and TEN exist on a spectrum of disease

2022-04-26T03:20:12Z

Causes

← Older revision		Revision as of 03:20, 26 April 2022
Line 16:		Line 16:
	*Immunosuppression - [[HIV]] <ref>Rotunda A, Hirsch RJ, Scheinfeld N, Weinberg JM. Severe cutaneous reactions associated with the use of human immunodeficiency virus medications. Acta Derm Venereol. 2003. 83(1):1-9. [Medline]</ref>		*Immunosuppression - [[HIV]] <ref>Rotunda A, Hirsch RJ, Scheinfeld N, Weinberg JM. Severe cutaneous reactions associated with the use of human immunodeficiency virus medications. Acta Derm Venereol. 2003. 83(1):1-9. [Medline]</ref>
	*Infectious - [[Mycoplasma pneumoniae]]<ref>Kunimi Y, Hirata Y, Aihara M, Yamane Y, Ikezawa Z. Statistical analysis of Stevens-Johnson syndrome caused by Mycoplasma pneumonia infection in Japan. Allergol Int. 2011;60(4):525-532. doi:10.2332/allergolint.11-OA-0309</ref>		*Infectious - [[Mycoplasma pneumoniae]]<ref>Kunimi Y, Hirata Y, Aihara M, Yamane Y, Ikezawa Z. Statistical analysis of Stevens-Johnson syndrome caused by Mycoplasma pneumonia infection in Japan. Allergol Int. 2011;60(4):525-532. doi:10.2332/allergolint.11-OA-0309</ref>
	*Autoimmune - SLE<ref>Horne NS, Narayan AR, Young RM, Frieri M. Toxic epidermal necrolysis in systemic lupus erythematosus. Autoimmun Rev. 2006 Feb. 5(2):160-4. [Medline]</ref>		*Autoimmune - [[SLE]]<ref>Horne NS, Narayan AR, Young RM, Frieri M. Toxic epidermal necrolysis in systemic lupus erythematosus. Autoimmun Rev. 2006 Feb. 5(2):160-4. [Medline]</ref>

	==Clinical Features==		==Clinical Features==

2021-04-19T09:44:53Z

2021-01-05T16:33:50Z

Causes

← Older revision		Revision as of 16:33, 5 January 2021
Line 15:		Line 15:
	*Idiopathic		*Idiopathic
	*Immunosuppression - [[HIV]] <ref>Rotunda A, Hirsch RJ, Scheinfeld N, Weinberg JM. Severe cutaneous reactions associated with the use of human immunodeficiency virus medications. Acta Derm Venereol. 2003. 83(1):1-9. [Medline]</ref>		*Immunosuppression - [[HIV]] <ref>Rotunda A, Hirsch RJ, Scheinfeld N, Weinberg JM. Severe cutaneous reactions associated with the use of human immunodeficiency virus medications. Acta Derm Venereol. 2003. 83(1):1-9. [Medline]</ref>
	*Infectious		*Infectious - [[Mycoplasma pneumoniae]]<ref>Kunimi Y, Hirata Y, Aihara M, Yamane Y, Ikezawa Z. Statistical analysis of Stevens-Johnson syndrome caused by Mycoplasma pneumonia infection in Japan. Allergol Int. 2011;60(4):525-532. doi:10.2332/allergolint.11-OA-0309</ref>
	*Autoimmune- SLE<ref>Horne NS, Narayan AR, Young RM, Frieri M. Toxic epidermal necrolysis in systemic lupus erythematosus. Autoimmun Rev. 2006 Feb. 5(2):160-4. [Medline]</ref>		*Autoimmune - SLE<ref>Horne NS, Narayan AR, Young RM, Frieri M. Toxic epidermal necrolysis in systemic lupus erythematosus. Autoimmun Rev. 2006 Feb. 5(2):160-4. [Medline]</ref>

	==Clinical Features==		==Clinical Features==

2020-12-21T18:38:53Z

Background

← Older revision		Revision as of 18:38, 21 December 2020
Line 3:		Line 3:
	* Mucous membranes can also be involved		* Mucous membranes can also be involved
	*SJS and TEN exist on a spectrum of disease		*SJS and TEN exist on a spectrum of disease
	**SJS involves <10% of the skin[[BSA]]		**SJS involves <10% of the skin [[BSA\|body surface area]]
	**TEN involves >30% of the skin[[BSA]]		**TEN involves >30% of the skin [[BSA\|body surface area]]
	*SJS and TEN are considered true dermatologic emergencies		*SJS and TEN are considered true dermatologic emergencies

2020-12-21T18:37:34Z

Background

← Older revision		Revision as of 18:37, 21 December 2020
Line 1:		Line 1:
	==Background==		==Background==
			* Stevens-Johnoen Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are a spectrum of disease which ultimately results in blistering and peeling of the skin
			* Mucous membranes can also be involved
	*SJS and TEN exist on a spectrum of disease		*SJS and TEN exist on a spectrum of disease
	**SJS involves <10% of [[BSA]]		**SJS involves <10% of the skin[[BSA]]
	**TEN involves >30% of [[BSA]]		**TEN involves >30% of the skin[[BSA]]
	*~~Dermatologic emergency~~		*SJS and TEN are considered true dermatologic emergencies

	===Causes===		===Causes===

2019-12-17T19:17:54Z

Evaluation

← Older revision		Revision as of 19:17, 17 December 2019
Line 50:		Line 50:
	===Evaluation===		===Evaluation===
	*Clinical diagnosis		*Clinical diagnosis
			{{Table of severe drug reactions}}

	==Management==		==Management==

2019-10-31T17:35:39Z

← Older revision		Revision as of 17:35, 31 October 2019
Line 34:		Line 34:
	*[[Erythroderma]]		*[[Erythroderma]]
	*[[Toxic Shock Syndrome]]		*[[Toxic Shock Syndrome]]
	*[[Drug ~~eruption~~]]		*[[Drug rash]]
	*[[Acute generalized exanthematous pustulosis]]		*[[Acute generalized exanthematous pustulosis]]
	*[[DRESS syndrome]]		*[[DRESS syndrome]]

← Older revision		Revision as of 09:44, 19 April 2021
Line 97:		Line 97:
	==See Also==		==See Also==
	*[[Rashes]]		*[[Rashes]]
			*[[Estimating body surface area]]

	==References==		==References==