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Danbot: Create lab page for Salicylate level with EM-focused content and references
2026-03-22T06:58:14Z
<p>Create lab page for Salicylate level with EM-focused content and references</p>
<p><b>New page</b></p><div>==Background==<br />
*Serum salicylate (aspirin) concentration<br />
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==Normal Values==<br />
*Therapeutic: 15-30 mg/dL<br />
*Toxicity: >30 mg/dL<br />
*Severe toxicity: >60 mg/dL<br />
*Potentially lethal: >90 mg/dL<br />
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==Interpretation==<br />
*Repeat levels every 2 hours until trending down; delayed absorption can occur with enteric-coated preparations or bezoar formation<br />
*Rising levels despite treatment or level >60 mg/dL: consider emergent dialysis<br />
*Classic ABG pattern: early respiratory alkalosis progressing to mixed respiratory alkalosis and metabolic acidosis<br />
*Acidemia increases CNS salicylate penetration and toxicity; avoid intubation if possible (loss of hyperventilation worsens acidosis)<ref>Palmer BF, et al. Salicylate toxicity. N Engl J Med. 2020; 382(26):2544-2555. PMID 32579814.</ref><br />
*Urine alkalinization (goal urine pH 7.5-8.0) enhances renal elimination<br />
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==See Also==<br />
*[[Salicylate toxicity]]<br />
*[[Toxicology]]<br />
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==References==<br />
<references/><br />
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[[Category:Labs]]</div>
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