Paget's disease of bone - Revision history

Rossdonaldson1: /* Evaluation */

2019-12-11T03:27:36Z

Evaluation

← Older revision		Revision as of 03:27, 11 December 2019
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	==Evaluation==		==Evaluation==
	[[File:Paget's disease R coxal.jpg\|thumb\|Paget's disease of right innominate bone.]]		[[File:Paget's disease R coxal.jpg\|thumb\|Paget's disease of right innominate bone.]]
			[[File:Pagets skull.jpg\|thumb\|Skull CT showing “cotton wool spots” typical of later stages of Paget’s disease.]]
	*Imaging to evaluate for [[fractures]]		*Imaging to evaluate for [[fractures]]
	**Initial lesion may be destructive, radiolucent (especially in skull)		**Initial lesion may be destructive, radiolucent (especially in skull)

Rossdonaldson1: /* Evaluation */

2019-12-11T03:25:51Z

Evaluation

← Older revision		Revision as of 03:25, 11 December 2019
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	==Evaluation==		==Evaluation==
			[[File:Paget's disease R coxal.jpg\|thumb\|Paget's disease of right innominate bone.]]
	*Imaging to evaluate for [[fractures]]		*Imaging to evaluate for [[fractures]]
	**Initial lesion may be destructive, radiolucent (especially in skull)		**Initial lesion may be destructive, radiolucent (especially in skull)

Rossdonaldson1: /* Differential Diagnosis */

2019-12-11T03:16:24Z

Differential Diagnosis

← Older revision		Revision as of 03:16, 11 December 2019
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	*Intramedullary osteosclerosis		*Intramedullary osteosclerosis
	*[[Sickle cell disease]]		*[[Sickle cell disease]]

			{{Bone tumors and their mimics DDX}}

	==Evaluation==		==Evaluation==

Rossdonaldson1: Rossdonaldson1 moved page Paget disease to Paget's disease of bone

2019-12-11T03:15:00Z

Rossdonaldson1 moved page Paget disease to Paget's disease of bone

← Older revision	Revision as of 03:15, 11 December 2019
(No difference)

Mtjordan91: /* Differential Diagnosis */

2019-11-21T21:33:37Z

Differential Diagnosis

← Older revision		Revision as of 21:33, 21 November 2019
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	==Differential Diagnosis==		==Differential Diagnosis==
	*Bone tumor (e.g. osteosarcoma or metastesis		*Bone tumor (e.g. [[osteosarcoma]] or metastesis)
	*[[Multiple myeloma]], [[myelofibrosis]]		*[[Multiple myeloma]], [[myelofibrosis]]
	*Fibrous dysplasia		*Fibrous dysplasia

ClaireLewis: Created page with "==Background== Characterized by areas of bone with excessive osteolytic activity and subsequent increased ostoblastic activity, resulting in disorganized bone formation Resu..."

2019-01-27T00:37:06Z

Created page with "==Background== *Characterized by areas of bone with excessive osteolytic activity and subsequent increased ostoblastic activity, resulting in disorganized bone formation *Resu..."

New page

==Background==
*Characterized by areas of bone with excessive osteolytic activity and subsequent increased ostoblastic activity, resulting in disorganized bone formation
*Results in osteolytic lesions and weakened bone
*Eventually, affected bones may be abnormally enlarged
*Exact etiology unknown, likely genetic component
*Prevalence increases with age, more common in people of European descent
==Clinical Features==
*Initially asymptomatic or mild pain
*Bone pain at affected sites, often worse at night
*Pathologic [[fractures]]
*If skull involved, may report increased hat size, [[headache]], decreased hearing

==Differential Diagnosis==
*Bone tumor (e.g. osteosarcoma or metastesis
*[[Multiple myeloma]], [[myelofibrosis]]
*Fibrous dysplasia
*Intramedullary osteosclerosis
*[[Sickle cell disease]]

==Evaluation==
*Imaging to evaluate for [[fractures]]
**Initial lesion may be destructive, radiolucent (especially in skull)
**Involved bones may be expanded, abnormally dense
**May have multiple fissure fractures in long bones
*Alk phos typically very high
*Serum calcium may be high

==Management==
*Treat [[fractures]]
*[[Pain control]]
*Bisphosphonates (e.g. Zoledronate) are treatment of choice for patients with severe symptoms or advanced disease

==Disposition==
*Discharge uncomplicated patients

==See Also==

==External Links==

==References==
<references/>

[[Category:Orthopedics]]

Paget's disease of bone - Revision history

Rossdonaldson1: /* Evaluation */

Rossdonaldson1: /* Evaluation */

Rossdonaldson1: /* Differential Diagnosis */

Rossdonaldson1: Rossdonaldson1 moved page Paget disease to Paget's disease of bone

Mtjordan91: /* Differential Diagnosis */

ClaireLewis: Created page with "==Background== *Characterized by areas of bone with excessive osteolytic activity and subsequent increased ostoblastic activity, resulting in disorganized bone formation *Resu..."

ClaireLewis: Created page with "==Background== Characterized by areas of bone with excessive osteolytic activity and subsequent increased ostoblastic activity, resulting in disorganized bone formation Resu..."