Robyn.levine: /* Special Populations */

2019-10-01T00:28:07Z

Special Populations

← Older revision		Revision as of 00:28, 1 October 2019
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	**CrCl <30 mL/min: do not use		**CrCl <30 mL/min: do not use
	**CrCl <60 mL/min: do not use for pre-exposure prophylaxis		**CrCl <60 mL/min: do not use for pre-exposure prophylaxis
			*Hepatic dosing
			has not been studied (see hepatotoxicity below)

	==Contraindications==		==Contraindications==

ClaireLewis: /* References */

2019-09-22T19:10:12Z

References

← Older revision		Revision as of 19:10, 22 September 2019
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

ClaireLewis: Created page with "==Administration== Type: Antiviral (antiretroviral) Dosage Forms: Routes of Administration: Oral Common Trade Names: Truvada ==Adult Dosing== *HIV pre- or post-exposu..."

2017-02-26T00:28:33Z

Created page with "==Administration== *Type: Antiviral (antiretroviral) *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: Truvada ==Adult Dosing== *HIV pre- or post-exposu..."

New page

==Administration==
*Type: [[Antiviral]] (antiretroviral)
*Dosage Forms:
*Routes of Administration: Oral
*Common Trade Names: Truvada

==Adult Dosing==
*HIV pre- or post-exposure prophylaxis: 1 tablet (emtricitabine 200 mg/tenofovir 300 mg) PO daily
*HIV infection: 1 tablet daily usually in combination with another agent

==Pediatric Dosing==
*17-22kg: Emtricitabine 100 mg/tenofovir 150 mg PO once daily
*22-28kg: Emtricitabine 133 mg/tenofovir 200 mg PO once daily
*28-36kg: Emtricitabine 167 mg/tenofovir 250 mg PO once daily
*>35kg: Emtricitabine 200 mg/tenofovir 300 mg PO once daily

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: B
*Lactation risk: Infant risk cannot be ruled out
*Renal dosing:
**CrCl 30-50 mL/min: 1 tablet every 48 hours
**CrCl <30 mL/min: do not use
**CrCl <60 mL/min: do not use for pre-exposure prophylaxis

==Contraindications==
*Allergy to class/drug
*Monotherapy for HIV infection
*Pre-exposure prophylaxis in patients with unknown HIV status

==Adverse Reactions==
===Serious===
*Hepatotoxicity
*Reactivation of hepatitis B
*Immune reconstitution syndrome
*Rhabdomyolysis
*Pancreatitis
*Renal failure
*Fanconi syndrome
===Common===
*Nausea, diarrhea, abdominal pain
*Rash
*Backache, myalgia, osteopenia
*Lactic acidosis
*Dizziness, fatigue, peripheral neuropathy, headache
*Depression, dream disorder, insomnia
*Pneumonia

==Pharmacology==
*Half-life: 10-17h
*Metabolism: Hepatic
*Excretion: Mostly renal

==Mechanism of Action==
*Both drugs nucleoside analogues that inhibit activity of HIV-1 reverse transcriptase

==Comments==

==See Also==
*[[HIV]]

==References==
<references/>

[[Category:Pharmacology]]

Emtricitabine/tenofovir - Revision history

Robyn.levine: /* Special Populations */

ClaireLewis: /* References */

ClaireLewis: Created page with "==Administration== *Type: Antiviral (antiretroviral) *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: Truvada ==Adult Dosing== *HIV pre- or post-exposu..."

ClaireLewis: Created page with "==Administration== Type: Antiviral (antiretroviral) Dosage Forms: Routes of Administration: Oral Common Trade Names: Truvada ==Adult Dosing== *HIV pre- or post-exposu..."