Dextromethorphan toxicity - Revision history

Imogen: /* Background */ seratonin -> serotonin

2025-08-21T22:45:07Z

Background: seratonin -> serotonin

← Older revision		Revision as of 22:45, 21 August 2025
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	==Background==		==Background==
	*Antitussive agent		*Antitussive agent
	*Acts on opioid and ~~seratonin~~ receptors		*Acts on opioid and serotonin receptors
	*At high doses has phencyclidine (PCP) and ketamine like effects on the NMDA receptor system		*At high doses has phencyclidine (PCP) and ketamine like effects on the NMDA receptor system
	*High abuse in 12-25 year olds for euphoric and dissociative properties		*High abuse in 12-25 year olds for euphoric and dissociative properties

2016-08-01T18:41:46Z

Text replacement - "doesn't" to "does not"

← Older revision		Revision as of 18:41, 1 August 2016
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	*Visual field distortion and dilated pupils		*Visual field distortion and dilated pupils
	*Excitement, euphoria, hallucinations, loss of time, feelings of dissociation, inappropriate laughing		*Excitement, euphoria, hallucinations, loss of time, feelings of dissociation, inappropriate laughing
	*Less respiratory depression compared to other opioids (~~doesn't~~ act on mu/delta receptors)		*Less respiratory depression compared to other opioids (does not act on mu/delta receptors)
	*Reactions with other medications		*Reactions with other medications
	**If anti-H1 in combination, [[Anticholinergic toxicity]]		**If anti-H1 in combination, [[Anticholinergic toxicity]]

2016-07-31T07:20:03Z

Text replacement - "opiates" to "opioids"

← Older revision		Revision as of 07:20, 31 July 2016
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	*Given altered mental status, key importance of witnesses and EMS recovery of medication bottles		*Given altered mental status, key importance of witnesses and EMS recovery of medication bottles
	*Acetaminophen level (combination cold medicine)		*Acetaminophen level (combination cold medicine)
	*Urine drug screen may be positive for PCP or ~~opiates~~		*Urine drug screen may be positive for PCP or opioids

	==Management==		==Management==

2016-07-30T11:26:06Z

Text replacement - "AMS" to "altered mental status"

← Older revision		Revision as of 11:26, 30 July 2016
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	==Evaluation==		==Evaluation==
	*Given ~~AMS~~, key importance of witnesses and EMS recovery of medication bottles		*Given altered mental status, key importance of witnesses and EMS recovery of medication bottles
	*Acetaminophen level (combination cold medicine)		*Acetaminophen level (combination cold medicine)
	*Urine drug screen may be positive for PCP or opiates		*Urine drug screen may be positive for PCP or opiates

2016-07-21T21:40:44Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 21:40, 21 July 2016
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	{{Hallucinogen types}}		{{Hallucinogen types}}

	==~~Diagnosis~~==		==Evaluation==
	*Given AMS, key importance of witnesses and EMS recovery of medication bottles		*Given AMS, key importance of witnesses and EMS recovery of medication bottles
	*Acetaminophen level (combination cold medicine)		*Acetaminophen level (combination cold medicine)

2016-07-18T20:45:02Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 20:45, 18 July 2016
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	Toxicity is dose dependant<ref>Logan BK, Yeakel JK, Goldfogel G, et al. Dextromethorphan abuse leading to assault, suicide, or homicide. J Forensic Sci 2012; 57:1388.</ref>		Toxicity is dose dependant<ref>Logan BK, Yeakel JK, Goldfogel G, et al. Dextromethorphan abuse leading to assault, suicide, or homicide. J Forensic Sci 2012; 57:1388.</ref>
	*Normal dose of nyquil (30 mL) has ~~30 mg~~ of dextromethorphan		*Normal dose of nyquil (30 mL) has 30mg of dextromethorphan
	{\| class="wikitable"		{\| class="wikitable"
	\|-		\|-
	! Plateau !! Dose !! Symptoms		! Plateau !! Dose !! Symptoms
	\|-		\|-
	\| 1 \|\| 100 to ~~200 mg~~ \|\| Mild stimulation, change in gravity perception		\| 1 \|\| 100 to 200mg \|\| Mild stimulation, change in gravity perception
	\|-		\|-
	\| 2 \|\| 200 to ~~400 mg~~ \|\| Euphoria and hallucinations		\| 2 \|\| 200 to 400mg \|\| Euphoria and hallucinations
	\|-		\|-
	\| 3 \|\| 300 to ~~600 mg~~ \|\| Dissociative and out of body sensation		\| 3 \|\| 300 to 600mg \|\| Dissociative and out of body sensation
	\|-		\|-
	\| 4 \|\| >~~600 mg~~ \|\| Complete dissociation and unresponsiveness, coma		\| 4 \|\| >600mg \|\| Complete dissociation and unresponsiveness, coma
	\|}		\|}

2016-07-04T12:12:43Z

Text replacement - "* " to "*"

← Older revision		Revision as of 12:12, 4 July 2016
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	*At high doses has phencyclidine (PCP) and ketamine like effects on the NMDA receptor system		*At high doses has phencyclidine (PCP) and ketamine like effects on the NMDA receptor system
	*High abuse in 12-25 year olds for euphoric and dissociative properties		*High abuse in 12-25 year olds for euphoric and dissociative properties
	** "Skittles", "Robotripping"		**"Skittles", "Robotripping"
	[[File:330px-DXM Doses.jpg\|thumbnail\|Bright red pills resemble skittles]]		[[File:330px-DXM Doses.jpg\|thumbnail\|Bright red pills resemble skittles]]

2016-03-22T16:23:12Z

Text replacement - "Category:Tox" to "Category:Toxicology"

2015-10-09T23:00:49Z

Differential Diagnosis

2015-10-09T07:38:12Z

← Older revision		Revision as of 07:38, 9 October 2015
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	==Clinical Features==		==Clinical Features==
	*Diaphoresis		*Diaphoresis, hyperthermia, tachycardia
	*Visual field distortion and dilated pupils		*Visual field distortion and dilated pupils
	*Excitement, euphoria, hallucinations, loss of time, feelings of dissociation, inappropriate laughing		*Excitement, euphoria, hallucinations, loss of time, feelings of dissociation, inappropriate laughing