Dabigatran reversal - Revision history

Josgood: /* Background */

2021-09-16T18:16:29Z

Background

← Older revision		Revision as of 18:16, 16 September 2021
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	==Background==		==Background==
			*Brand name Pradaxa
	*If aPTT is <1.5 x control, it is unlikely that significant drug effect is present		*If aPTT is <1.5 x control, it is unlikely that significant drug effect is present
	*Thrombin Time (TT) is most sensitive; normal TT excludes presence of significant dabigatran		*Thrombin Time (TT) is most sensitive; normal TT excludes presence of significant dabigatran

2021-03-08T16:21:25Z

2019-10-01T00:18:28Z

← Older revision		Revision as of 00:18, 1 October 2019
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	*Delay next 1-2 doses '''OR''' discontinue (as appropriate)		*Delay next 1-2 doses '''OR''' discontinue (as appropriate)

	==Moderate-Severe Bleeding==		==[[hemorrhage\|Moderate-Severe Bleeding]]==
	*Local control measures: direct pressure/surgical intervention		*Local control measures: direct pressure/surgical intervention
	*Resuscitate with intravenous fluid and / blood products		*Resuscitate with intravenous [[IVF\|fluid]] and / [[blood products]]
	*Oral [[charcoal]] administration ''if drug taken <2 hours before presentation''		*Oral [[charcoal]] administration ''if drug taken <2 hours before presentation''
	*Hemodialysis will remove ~60% of drug taken over prior 2-3 hours		*[[Hemodialysis]] will remove ~60% of drug taken over prior 2-3 hours
	*Consider [[Idarucizumab]] ([[Praxbind]]): 5 grams IV		*Consider [[Idarucizumab]] ([[Praxbind]]): 5 grams IV

	==Life-Threatening Bleeding==		==[[hemorrhage\|Life-Threatening Bleeding]]==
	*[[Idarucizumab]] (Praxbind): 5 grams IV		*[[Idarucizumab]] (Praxbind): 5 grams IV

2017-05-30T22:26:08Z

Text replacement - "OR" to "'''OR'''"

← Older revision		Revision as of 22:26, 30 May 2017
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	==Mild Bleeding==		==Mild Bleeding==
	*Local control measures: direct pressure		*Local control measures: direct pressure
	*Delay next 1-2 doses OR discontinue (as appropriate)		*Delay next 1-2 doses '''OR''' discontinue (as appropriate)

	==Moderate-Severe Bleeding==		==Moderate-Severe Bleeding==

2016-05-06T11:02:27Z

Life-Threatening Bleeding

← Older revision		Revision as of 11:02, 6 May 2016
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	*Consider Recombinant Factor VIIa (no good data)		*Consider Recombinant Factor VIIa (no good data)
	*Consider [[Prothrombin Complex Concentrate\|Kcentra]] (PCC): 50 IU/kg IV bolus<ref>Eerenberg ES, et al. "Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate: A randomized, placebo-controlled, crossover study in healthy subjects". Circulation. 2011 Sep 6.</ref>		*Consider [[Prothrombin Complex Concentrate\|Kcentra]] (PCC): 50 IU/kg IV bolus<ref>Eerenberg ES, et al. "Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate: A randomized, placebo-controlled, crossover study in healthy subjects". Circulation. 2011 Sep 6.</ref>
			*Consider Tranexamic acid

	==See Also==		==See Also==

2016-04-03T13:40:03Z

2016-03-22T15:54:28Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

2015-12-19T23:00:52Z

Moderate-Severe Bleeding

← Older revision		Revision as of 23:00, 19 December 2015
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	*Oral [[charcoal]] administration ''if drug taken <2 hours before presentation''		*Oral [[charcoal]] administration ''if drug taken <2 hours before presentation''
	*Hemodialysis will remove ~60% of drug taken over prior 2-3 hours		*Hemodialysis will remove ~60% of drug taken over prior 2-3 hours
	*Consider [[Idarucizumab]] (Praxbind): 5 grams IV		*Consider [[Idarucizumab]] ([[Praxbind]]): 5 grams IV

	==Life-Threatening Bleeding==		==Life-Threatening Bleeding==

2015-12-15T12:03:53Z

← Older revision	Revision as of 12:03, 15 December 2015
(No difference)

2015-12-14T13:03:40Z

← Older revision		Revision as of 13:03, 14 December 2015
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	*Oral [[charcoal]] administration ''if drug taken <2 hours before presentation''		*Oral [[charcoal]] administration ''if drug taken <2 hours before presentation''
	*Hemodialysis will remove ~60% of drug taken over prior 2-3 hours		*Hemodialysis will remove ~60% of drug taken over prior 2-3 hours
			*Consider [[Idarucizumab]] (Praxbind): 5 grams IV

	==Life-Threatening Bleeding==		==Life-Threatening Bleeding==

← Older revision		Revision as of 16:21, 8 March 2021
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	==See Also==		==See Also==
	*[[Coagulopathy (Main)]]		*[[Coagulopathy (Main)]]
			*[[Anticoagulants]]
	*[[Idarucizumab]]		*[[Idarucizumab]]
	*[[Anticoagulant reversal for life-threatening bleeds]]		*[[Anticoagulant reversal for life-threatening bleeds]]

← Older revision		Revision as of 13:40, 3 April 2016
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	*[[Coagulopathy (Main)]]		*[[Coagulopathy (Main)]]
	*[[Idarucizumab]]		*[[Idarucizumab]]
			*[[Anticoagulant reversal for life-threatening bleeds]]

	==References==		==References==