Bone loss of spaceflight - Revision history

Rossdonaldson1 at 17:20, 5 February 2025

2025-02-05T17:20:30Z

← Older revision		Revision as of 17:20, 5 February 2025
Line 27:		Line 27:
	**Femoral neck: squats		**Femoral neck: squats
	**Hips: Jump exercises		**Hips: Jump exercises

			==Disposition==

	==See Also==		==See Also==
	*[[Space medicine]]		*[[Space medicine]]

			==External Links==

	==References==		==References==

Rossdonaldson1: /* Postflight bone mineral density rehab */

2025-02-05T17:20:01Z

Postflight bone mineral density rehab

← Older revision		Revision as of 17:20, 5 February 2025
Line 20:		Line 20:
	**Bisphosphonates - inhibit osteoclastic resorption but do not prevent muscle function declines		**Bisphosphonates - inhibit osteoclastic resorption but do not prevent muscle function declines

	==Postflight bone mineral density rehab==		===Postflight bone mineral density rehab===
	*Depending on mineral loss percentages and affected regions, astronauts undergo progressive weight exercises		*Depending on mineral loss percentages and affected regions, astronauts undergo progressive weight exercises
	**Spine: deadlifts and squats		**Spine: deadlifts and squats

Rossdonaldson1 at 17:19, 5 February 2025

2025-02-05T17:19:46Z

← Older revision		Revision as of 17:19, 5 February 2025
Line 1:		Line 1:
	==Physiology==		==Background==
			===Physiology===
	*Bone remodeling a continuous process where osteoclasts resorb old bone and osteoblasts form new bone. In microgravity, this balance is disrupted, leading to increased resorption and decreased formation. Weight-bearing bones, such as the hips and spine, are most affected due to the lack of gravitational stress.		*Bone remodeling a continuous process where osteoclasts resorb old bone and osteoblasts form new bone. In microgravity, this balance is disrupted, leading to increased resorption and decreased formation. Weight-bearing bones, such as the hips and spine, are most affected due to the lack of gravitational stress.
	*Calcium balance can be calculated as the difference between dietary intake and fecal and urinary excretion		*Calcium balance can be calculated as the difference between dietary intake and fecal and urinary excretion

	==~~Overview~~==		==Clinical Features==
	*In a six month’s duration, total body mineral density loss averages:<ref>Grigoriev AI, Oganov VS, Bakulin AV, Polyakov VV, Voronin LI, Morgun VV, Schneider VS, Marachko LM, Novikov, VE, LeBlanc AD, Shackelford LC. Clinicophysiological evaluation of bone changes in cosmonauts after long-term space missions. Aerosp Environ Med (Russia) 1998; 32(1):21–25.</ref>		*In a six month’s duration, total body mineral density loss averages:<ref>Grigoriev AI, Oganov VS, Bakulin AV, Polyakov VV, Voronin LI, Morgun VV, Schneider VS, Marachko LM, Novikov, VE, LeBlanc AD, Shackelford LC. Clinicophysiological evaluation of bone changes in cosmonauts after long-term space missions. Aerosp Environ Med (Russia) 1998; 32(1):21–25.</ref>
	**Pelvis - 12%		**Pelvis - 12%
Line 13:		Line 14:
	{{Space medicine}}		{{Space medicine}}

	==Mission countermeasures==		==Management==
			===Mission countermeasures===
	*Weighted exercise although often peformed do not inhibit spaceflight associated bone loss		*Weighted exercise although often peformed do not inhibit spaceflight associated bone loss
	*Pharmaceuticals:		*Pharmaceuticals:

Rossdonaldson1: /* References */

2025-02-05T17:13:38Z

References

← Older revision		Revision as of 17:13, 5 February 2025
Line 25:		Line 25:
	**Femoral neck: squats		**Femoral neck: squats
	**Hips: Jump exercises		**Hips: Jump exercises

			==See Also==
			*[[Space medicine]]

	==References==		==References==

Rossdonaldson1 at 17:07, 5 February 2025

2025-02-05T17:07:08Z

← Older revision		Revision as of 17:07, 5 February 2025
Line 9:		Line 9:
	**Femoral neck -8%		**Femoral neck -8%
	*There is significant variability with bone loss and most astronauts do no fully preflight density<ref> Harm DL, Jennings RT, Meck JV, Powell MR, Putcha L, Sams CP, Schneider SM, Shackelford LC, Smith SM, Whitson PA. Genome and Hormones: Gender differences in physiology. Invited review: Gender issues related to spaceflight: A NASA Perspective. J Appl Physiol 2001; 91: 2374–2383</ref>		*There is significant variability with bone loss and most astronauts do no fully preflight density<ref> Harm DL, Jennings RT, Meck JV, Powell MR, Putcha L, Sams CP, Schneider SM, Shackelford LC, Smith SM, Whitson PA. Genome and Hormones: Gender differences in physiology. Invited review: Gender issues related to spaceflight: A NASA Perspective. J Appl Physiol 2001; 91: 2374–2383</ref>

			==Differential Diagnosis==
			{{Space medicine}}

	==Mission countermeasures==		==Mission countermeasures==

Rossdonaldson1: /* References */

2025-02-05T16:49:45Z

References

← Older revision		Revision as of 16:49, 5 February 2025
Line 25:		Line 25:
	==References==		==References==
	<references/>		<references/>

			[[Category:Space Medicine]]

Ostermayer: /* Mission countermeasures */

2025-02-03T21:29:06Z

Mission countermeasures

← Older revision		Revision as of 21:29, 3 February 2025
Line 12:		Line 12:
	==Mission countermeasures==		==Mission countermeasures==
	*Weighted exercise although often peformed do not inhibit spaceflight associated bone loss		*Weighted exercise although often peformed do not inhibit spaceflight associated bone loss
			*Pharmaceuticals:
			**Bisphosphonates - inhibit osteoclastic resorption but do not prevent muscle function declines

	==Postflight bone mineral density rehab==		==Postflight bone mineral density rehab==

Ostermayer at 21:22, 3 February 2025

2025-02-03T21:22:44Z

← Older revision		Revision as of 21:22, 3 February 2025
Line 9:		Line 9:
	**Femoral neck -8%		**Femoral neck -8%
	*There is significant variability with bone loss and most astronauts do no fully preflight density<ref> Harm DL, Jennings RT, Meck JV, Powell MR, Putcha L, Sams CP, Schneider SM, Shackelford LC, Smith SM, Whitson PA. Genome and Hormones: Gender differences in physiology. Invited review: Gender issues related to spaceflight: A NASA Perspective. J Appl Physiol 2001; 91: 2374–2383</ref>		*There is significant variability with bone loss and most astronauts do no fully preflight density<ref> Harm DL, Jennings RT, Meck JV, Powell MR, Putcha L, Sams CP, Schneider SM, Shackelford LC, Smith SM, Whitson PA. Genome and Hormones: Gender differences in physiology. Invited review: Gender issues related to spaceflight: A NASA Perspective. J Appl Physiol 2001; 91: 2374–2383</ref>

			==Mission countermeasures==
			*Weighted exercise although often peformed do not inhibit spaceflight associated bone loss

	==Postflight bone mineral density rehab==		==Postflight bone mineral density rehab==

Ostermayer: /* Physiology */

2025-02-03T21:19:28Z

Physiology

← Older revision		Revision as of 21:19, 3 February 2025
Line 1:		Line 1:
	==Physiology==		==Physiology==
	*Bone remodeling a continuous process where osteoclasts resorb old bone and osteoblasts form new bone. In microgravity, this balance is disrupted, leading to increased resorption and decreased formation. Weight-bearing bones, such as the hips and spine, are most affected due to the lack of gravitational stress.		*Bone remodeling a continuous process where osteoclasts resorb old bone and osteoblasts form new bone. In microgravity, this balance is disrupted, leading to increased resorption and decreased formation. Weight-bearing bones, such as the hips and spine, are most affected due to the lack of gravitational stress.
			*Calcium balance can be calculated as the difference between dietary intake and fecal and urinary excretion

	==Overview==		==Overview==

Ostermayer: /* Monitoring during spaceflight */

2025-02-03T21:19:20Z

Monitoring during spaceflight

← Older revision		Revision as of 21:19, 3 February 2025
Line 8:		Line 8:
	**Femoral neck -8%		**Femoral neck -8%
	*There is significant variability with bone loss and most astronauts do no fully preflight density<ref> Harm DL, Jennings RT, Meck JV, Powell MR, Putcha L, Sams CP, Schneider SM, Shackelford LC, Smith SM, Whitson PA. Genome and Hormones: Gender differences in physiology. Invited review: Gender issues related to spaceflight: A NASA Perspective. J Appl Physiol 2001; 91: 2374–2383</ref>		*There is significant variability with bone loss and most astronauts do no fully preflight density<ref> Harm DL, Jennings RT, Meck JV, Powell MR, Putcha L, Sams CP, Schneider SM, Shackelford LC, Smith SM, Whitson PA. Genome and Hormones: Gender differences in physiology. Invited review: Gender issues related to spaceflight: A NASA Perspective. J Appl Physiol 2001; 91: 2374–2383</ref>

	~~==Monitoring during spaceflight==~~
	*Calcium balance can be calculated as the difference between dietary intake and fecal and urinary excretion


	==Postflight bone mineral density rehab==		==Postflight bone mineral density rehab==