Azathioprine - Revision history

Elcatracho: /* See Also */

2021-03-08T19:46:28Z

Elcatracho: /* Rheumatoid arthritis, severe */

2021-03-08T19:45:28Z

Rheumatoid arthritis, severe

← Older revision		Revision as of 19:45, 8 March 2021
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	*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary		*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary

	===Rheumatoid arthritis, severe===		===[[Rheumatoid arthritis]], severe===
	*1-2.5mg/kg/day PO divided QD-bid		*1-2.5mg/kg/day PO divided QD-bid
	*Start: 1mg/kg/day PO divided QD-bid; Max: 2.5mg/kg/day; Info: after 6-8wk may increase 0.5mg/kg/day q4wk		*Start: 1mg/kg/day PO divided QD-bid; Max: 2.5mg/kg/day; Info: after 6-8wk may increase 0.5mg/kg/day q4wk

Fletc151: /* References */

2019-06-10T13:03:52Z

References

← Older revision		Revision as of 13:03, 10 June 2019
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	==References==		==References==
			*A randomised clinical trial comparing prednisone and azathioprine in myasthenia gravis. Results of the second interim analysis. Myasthenia Gravis Clinical Study Group. J Neurol Neurosurg Psychiatry. 1993;56(11):1157-1163. [PubMed 8229026]
			*American College of Rheumatology Ad Hoc Committee on Clinical Guidelines, “Guidelines for Monitoring Drug Therapy in Rheumatoid Arthritis,” Arthritis Rheum, 1996, 39(5):723-31. [PubMed 8639168]
			*Astey AV, Wakelin S, and Reynolds NJ, “Guidelines for Prescribing Azathioprine in Dermatology,” Br J Dermatol, 2004, 151(6):1123-32. [PubMed 15606506]
			*Armuzzi A, Felice C, Papa A, et al. Prevention of postoperative recurrence with azathioprine or infliximab in patients with Crohn's disease: an open-label pilot study. J Crohns Colitis. 2013;7(12):e623-e629. doi: 10.1016/j.crohns.2013.04.020. [PubMed 23810678]
			*Arnold DM, Nazi I, Santos A, et al, “Combination Immunosuppressant Therapy for Patients With Chronic Refractory Immune Thrombocytopenic Purpura,” Blood, 2010, 115(1):29-31. [PubMed 19897578]
			*Aronoff GR, Bennett WM, Berns JS, et al, Drug Prescribing in Renal Failure: Dosing Guidelines for Adults and Children, 5th ed. Philadelphia, PA: American College of Physicians; 2007, p 97, 177.
			*Azasan (azathioprine) [prescribing information]. Bridgewater, NJ: Salix Pharmaceuticals; March 2019.
			*Azathioprine injection [prescribing information]. Eatontown, NJ: West-Ward Pharmaceuticals; August 2015.
			*Baum D, Bernstein D, Starnes VA, et al, “Pediatric Heart Transplantation at Stanford: Results of a 15-Year Experience,” Pediatrics, 1991, 88(2):203-14. [PubMed 1861916]
			*Beissert S, Werfel T, Frieling U, et al, "A Comparison of Oral Methylprednisolone Plus Azathioprine or Mycophenolate Mofetil for the Treatment of Pemphigus," Arch Dermatol, 2006, 142(11):1447-54. [PubMed 17116835]

	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	epocrates		epocrates

Humanguy: edited dosage form, strength, routes of administration

2017-10-11T22:20:01Z

edited dosage form, strength, routes of administration

← Older revision		Revision as of 22:20, 11 October 2017
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	==Administration==		==Administration==
	*Type: immunosuppressant		*Type: immunosuppressant
	*Dosage Forms: 50		*Dosage Forms: tablet, powder for injection (IV form unavailable in US)
	*Routes of Administration: PO (~~IV form~~ unavailable in US)		*Dosage Strengths: tablet: 50, 75, 100mg; powder for injection: 100mg/vial
			*Routes of Administration: PO, IV (unavailable in US)
	*Common Trade Names: Azasan, Imuran		*Common Trade Names: Azasan, Imuran

Mholtz: Text replacement - "qd" to "QD"

2017-07-07T08:03:26Z

Text replacement - "qd" to "QD"

← Older revision		Revision as of 08:03, 7 July 2017
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	==Adult Dosing==		==Adult Dosing==
	===Kidney transplant rejection prophylaxis===		===Kidney transplant rejection prophylaxis===
	*1-3mg/kg PO qd		*1-3mg/kg PO QD
	*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary		*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary

	===Rheumatoid arthritis, severe===		===Rheumatoid arthritis, severe===
	*1-2.5mg/kg/day PO divided qd-bid		*1-2.5mg/kg/day PO divided QD-bid
	*Start: 1mg/kg/day PO divided qd-bid; Max: 2.5mg/kg/day; Info: after 6-8wk may increase 0.5mg/kg/day q4wk		*Start: 1mg/kg/day PO divided QD-bid; Max: 2.5mg/kg/day; Info: after 6-8wk may increase 0.5mg/kg/day q4wk

	===Crohns Disease===		===Crohns Disease===
	*100-250mg PO qd		*100-250mg PO QD
	*Start: 50mg PO qd; Max: 2.5mg/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects		*Start: 50mg PO QD; Max: 2.5mg/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects

	===Ulcerative colitis===		===Ulcerative colitis===
	*100-250mg PO qd		*100-250mg PO QD
	*Start: 50mg PO qd; Max: 2.5mg/kg/day; Info: for induction or remission maintenance, steroid-sparing effects		*Start: 50mg PO QD; Max: 2.5mg/kg/day; Info: for induction or remission maintenance, steroid-sparing effects

	==Pediatric Dosing==		==Pediatric Dosing==
	===Kidney transplant rejection prophylaxis===		===Kidney transplant rejection prophylaxis===
	*1-3mg/kg PO qd		*1-3mg/kg PO QD
	*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary		*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary

	===Juvenile idiopathic arthritis, severe===		===Juvenile idiopathic arthritis, severe===
	*1-2.5mg/kg/day PO divided qd-bid		*1-2.5mg/kg/day PO divided QD-bid
	*Start: 1mg/kg/day PO divided qd-bid; Max: 2.5mg/kg/day; Info: after 6-8wk may increase 0.5mg/kg/day q4wk		*Start: 1mg/kg/day PO divided QD-bid; Max: 2.5mg/kg/day; Info: after 6-8wk may increase 0.5mg/kg/day q4wk

	==Special Populations==		==Special Populations==

Neil.m.young: Text replacement - "3 mg" to "3mg"

2016-07-21T11:12:06Z

Text replacement - "3 mg" to "3mg"

← Older revision		Revision as of 11:12, 21 July 2016
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	==Adult Dosing==		==Adult Dosing==
	===Kidney transplant rejection prophylaxis===		===Kidney transplant rejection prophylaxis===
	*1-~~3 mg~~/kg PO qd		*1-3mg/kg PO qd
	*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary		*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary

Line 24:		Line 24:
	==Pediatric Dosing==		==Pediatric Dosing==
	===Kidney transplant rejection prophylaxis===		===Kidney transplant rejection prophylaxis===
	*1-~~3 mg~~/kg PO qd		*1-3mg/kg PO qd
	*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary		*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary

Neil.m.young: Text replacement - "5 mg" to "5mg"

2016-07-19T10:17:47Z

Text replacement - "5 mg" to "5mg"

← Older revision		Revision as of 10:17, 19 July 2016
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	===Kidney transplant rejection prophylaxis===		===Kidney transplant rejection prophylaxis===
	*1-3 mg/kg PO qd		*1-3 mg/kg PO qd
	*Start: 3-~~5 mg~~/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary		*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary

	===Rheumatoid arthritis, severe===		===Rheumatoid arthritis, severe===
	*1-2.~~5 mg~~/kg/day PO divided qd-bid		*1-2.5mg/kg/day PO divided qd-bid
	*Start: 1mg/kg/day PO divided qd-bid; Max: 2.~~5 mg~~/kg/day; Info: after 6-8wk may increase 0.~~5 mg~~/kg/day q4wk		*Start: 1mg/kg/day PO divided qd-bid; Max: 2.5mg/kg/day; Info: after 6-8wk may increase 0.5mg/kg/day q4wk

	===Crohns Disease===		===Crohns Disease===
	*100-250mg PO qd		*100-250mg PO qd
	*Start: 50mg PO qd; Max: 2.~~5 mg~~/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects		*Start: 50mg PO qd; Max: 2.5mg/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects

	===Ulcerative colitis===		===Ulcerative colitis===
	*100-250mg PO qd		*100-250mg PO qd
	*Start: 50mg PO qd; Max: 2.~~5 mg~~/kg/day; Info: for induction or remission maintenance, steroid-sparing effects		*Start: 50mg PO qd; Max: 2.5mg/kg/day; Info: for induction or remission maintenance, steroid-sparing effects

	==Pediatric Dosing==		==Pediatric Dosing==
	===Kidney transplant rejection prophylaxis===		===Kidney transplant rejection prophylaxis===
	*1-3 mg/kg PO qd		*1-3 mg/kg PO qd
	*Start: 3-~~5 mg~~/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary		*Start: 3-5mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary

	===Juvenile idiopathic arthritis, severe===		===Juvenile idiopathic arthritis, severe===
	*1-2.~~5 mg~~/kg/day PO divided qd-bid		*1-2.5mg/kg/day PO divided qd-bid
	*Start: 1mg/kg/day PO divided qd-bid; Max: 2.~~5 mg~~/kg/day; Info: after 6-8wk may increase 0.~~5 mg~~/kg/day q4wk		*Start: 1mg/kg/day PO divided qd-bid; Max: 2.5mg/kg/day; Info: after 6-8wk may increase 0.5mg/kg/day q4wk

	==Special Populations==		==Special Populations==
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	*[[Lactation risk categories\|Lactation risk]]: possibly unsafe		*[[Lactation risk categories\|Lactation risk]]: possibly unsafe
	===Renal Dosing===		===Renal Dosing===
	*Adult: CrCl 10-50: decrease dose 25%; CrCl <10: decrease dose 50%; HD: give 0.~~25 mg~~/kg supplement; PD: not defined		*Adult: CrCl 10-50: decrease dose 25%; CrCl <10: decrease dose 50%; HD: give 0.25mg/kg supplement; PD: not defined
	*Pediatric: CrCl 10-50: decrease dose 25% or give q36h; CrCl <10: decrease dose 50% or give q48h; HD: give supplement; PD: not defined		*Pediatric: CrCl 10-50: decrease dose 25% or give q36h; CrCl <10: decrease dose 50% or give q48h; HD: give supplement; PD: not defined

Neil.m.young: Text replacement - "1 mg" to "1mg"

2016-07-18T23:01:34Z

Text replacement - "1 mg" to "1mg"

← Older revision		Revision as of 23:01, 18 July 2016
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	===Rheumatoid arthritis, severe===		===Rheumatoid arthritis, severe===
	*1-2.5 mg/kg/day PO divided qd-bid		*1-2.5 mg/kg/day PO divided qd-bid
	*Start: ~~1 mg~~/kg/day PO divided qd-bid; Max: 2.5 mg/kg/day; Info: after 6-8wk may increase 0.5 mg/kg/day q4wk		*Start: 1mg/kg/day PO divided qd-bid; Max: 2.5 mg/kg/day; Info: after 6-8wk may increase 0.5 mg/kg/day q4wk

	===Crohns Disease===		===Crohns Disease===
Line 29:		Line 29:
	===Juvenile idiopathic arthritis, severe===		===Juvenile idiopathic arthritis, severe===
	*1-2.5 mg/kg/day PO divided qd-bid		*1-2.5 mg/kg/day PO divided qd-bid
	*Start: ~~1 mg~~/kg/day PO divided qd-bid; Max: 2.5 mg/kg/day; Info: after 6-8wk may increase 0.5 mg/kg/day q4wk		*Start: 1mg/kg/day PO divided qd-bid; Max: 2.5 mg/kg/day; Info: after 6-8wk may increase 0.5 mg/kg/day q4wk

	==Special Populations==		==Special Populations==

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-18T22:16:35Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 22:16, 18 July 2016
Line 15:		Line 15:

	===Crohns Disease===		===Crohns Disease===
	*100-~~250 mg~~ PO qd		*100-250mg PO qd
	*Start: ~~50 mg~~ PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects		*Start: 50mg PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects

	===Ulcerative colitis===		===Ulcerative colitis===
	*100-~~250 mg~~ PO qd		*100-250mg PO qd
	*Start: ~~50 mg~~ PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance, steroid-sparing effects		*Start: 50mg PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance, steroid-sparing effects

	==Pediatric Dosing==		==Pediatric Dosing==

ClaireLewis: /* Renal Dosing */

2016-07-15T20:51:10Z

Renal Dosing

← Older revision		Revision as of 20:51, 15 July 2016
Line 35:		Line 35:
	*[[Lactation risk categories\|Lactation risk]]: possibly unsafe		*[[Lactation risk categories\|Lactation risk]]: possibly unsafe
	===Renal Dosing===		===Renal Dosing===
	*Adult: CrCl 10-50: ~~decr.~~ dose 25%; CrCl <10: ~~decr.~~ dose 50%; HD: give 0.25 mg/kg supplement; PD: not defined		*Adult: CrCl 10-50: decrease dose 25%; CrCl <10: decrease dose 50%; HD: give 0.25 mg/kg supplement; PD: not defined
	*Pediatric: CrCl 10-50: ~~decr.~~ dose 25% or give q36h; CrCl <10: ~~decr.~~ dose 50% or give q48h; HD: give supplement; PD: not defined		*Pediatric: CrCl 10-50: decrease dose 25% or give q36h; CrCl <10: decrease dose 50% or give q48h; HD: give supplement; PD: not defined

	===Hepatic Dosing===		===Hepatic Dosing===

← Older revision		Revision as of 19:46, 8 March 2021
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	==See Also==		==See Also==
			*[[Transplant complications]]

	==References==		==References==