View source for Template:Renal tubular disorders DDX

===Renal tubular disorders===
*Salt-wasting tubulopathies
**[[Gitelman syndrome]] — distal convoluted tubule (NCC defect); hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis
**[[Bartter syndrome]] — thick ascending limb (NKCC2/ROMK/ClC-Kb defect); hypokalemia, hypercalciuria, metabolic alkalosis
**[[Liddle syndrome]] — collecting duct (ENaC gain-of-function); hypokalemia, hypertension, metabolic alkalosis
*Renal tubular acidosis
**[[Renal tubular acidosis]] type I (distal) — hypokalemia, metabolic acidosis, nephrocalcinosis
**[[Renal tubular acidosis]] type II (proximal) — hypokalemia, metabolic acidosis, Fanconi syndrome
**[[Renal tubular acidosis]] type IV — hyperkalemia, metabolic acidosis, hypoaldosteronism
*Inherited disorders of tubular transport
**[[Cystinuria]] — proximal tubule amino acid transport defect; recurrent cystine stones
**Fanconi syndrome — proximal tubule generalized dysfunction; glucosuria, aminoaciduria, phosphaturia
**[[Nephrogenic diabetes insipidus]] — collecting duct (aquaporin/V2R defect); polyuria, hypernatremia
**Dent disease — proximal tubule (ClC-5 defect); low molecular weight proteinuria, nephrocalcinosis
*Acquired tubulopathies
**Diuretic use/abuse (thiazide mimics Gitelman; loop mimics Bartter)
**[[Aminoglycosides]] nephrotoxicity
**[[Cisplatin]] nephrotoxicity
**[[Amphotericin B]] nephrotoxicity
**[[Lithium]]-induced nephrogenic DI